Insulin signaling in mouse oocytes.

  title={Insulin signaling in mouse oocytes.},
  author={Nicole Acevedo and Jun Ding and Gary Daniel Smith},
  journal={Biology of reproduction},
  volume={77 5},
Continuous exposure of follicles/oocytes to elevated levels of insulin compromises embryonic developmental competence, although the underlying cellular mechanisms are unknown. The objectives of the present study were to determine whether mouse oocytes have insulin receptors and a functional insulin signaling cascade, and whether insulin exposure during oocyte growth or maturation influences meiotic progression and chromatin remodeling. Immunoblot and immunocytochemical analyses of germinal… CONTINUE READING
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