Insulin signaling in adipocytes differentiated from mouse stromal MC3T3-G2/PA6 cells.

@article{Morito2005InsulinSI,
  title={Insulin signaling in adipocytes differentiated from mouse stromal MC3T3-G2/PA6 cells.},
  author={Satoshi Morito and K. Yaguchi and M. Imada and C. Tachikawa and M. Nomura and S. Moritani and M. Igarashi and K. Yokogawa and K. Miyamoto},
  journal={Biological \& pharmaceutical bulletin},
  year={2005},
  volume={28 11},
  pages={
          2040-5
        }
}
The stromal MC3T3-G2/PA6 (PA6) cells from mouse clavaria did not require insulin for differentiation into mature adipose cells, although insulin is well known to play a key role in adipocyte differentiation. Large lipid droplets were observed in the cytoplasm of PA6 cells, and mRNA expression of the adipose specific proteins (aP2, PPARgamma, C/EBPalpha, FAS, GLUT4, leptin, and adiponectin) as differentiation markers appeared or increased clearly in the cells at 8 d after stimulation without… Expand
Role of adrenomedullin system in lipid metabolism and its signaling mechanism in cultured adipocytes.
Adipocytes derived from PA6 cells reliably promote the differentiation of dopaminergic neurons from human embryonic stem cells
Impaired bone development and increased mesenchymal progenitor cells in calvaria of RB1−/− mice
Dopaminergic Differentiation of Human Embryonic Stem Cells on PA6-Derived Adipocytes.

References

SHOWING 1-10 OF 43 REFERENCES
Requirement for phosphoinositide 3-kinase in insulin-stimulated GLUT4 translocation in 3T3-L1 adipocytes.
Transcriptional regulation of gene expression during adipocyte differentiation.
...
1
2
3
4
5
...