Insulin signaling and the regulation of glucose transport.

  title={Insulin signaling and the regulation of glucose transport.},
  author={Louise Chang and S Chiang and Alan R. Saltiel},
  journal={Molecular medicine},
  volume={10 7-12},
Gaps remain in our understanding of the precise molecular mechanisms by which insulin regulates glucose uptake in fat and muscle cells. Recent evidence suggests that insulin action involves multiple pathways, each compartmentalized in discrete domains. Upon activation, the receptor catalyzes the tyrosine phosphorylation of a number of substrates. One family of these, the insulin receptor substrate (IRS) proteins, initiates activation of the phosphatidylinositol 3-kinase pathway, resulting in… CONTINUE READING
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