Insulin signaling and glucose transport in insulin resistant human skeletal muscle

@article{Karlsson2007InsulinSA,
  title={Insulin signaling and glucose transport in insulin resistant human skeletal muscle},
  author={H{\aa}kan K. R. Karlsson and Juleen R Zierath},
  journal={Cell Biochemistry and Biophysics},
  year={2007},
  volume={48},
  pages={103-113}
}
Insulin increases glucose uptake and metabolism in skeletal muscle by signal transduction via protein phosphorylation cascades. Insulin action on signal transduction is impaired in skeletal muscle from Type 2 diabetic subjects, underscoring the contribution of molecular defects to the insulin resistant phenotype. This review summarizes recent work to identify downstream intermediates in the insulin signaling pathways governing glucose homeostasis, in an attempt to characterize the molecular… CONTINUE READING

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