Insulin signal transduction pathways and insulin-induced gene expression.

  title={Insulin signal transduction pathways and insulin-induced gene expression.},
  author={Adam B. Keeton and Maggie O Amsler and Derwei Y Venable and Joseph Messina},
  journal={The Journal of biological chemistry},
  volume={277 50},
Insulin regulates metabolic activity, gene transcription, and cell growth by modulating the activity of several intracellular signaling pathways. Insulin activation of one mitogen-activated protein kinase cascade, the MEK/ERK kinase cascade, is well described. However, the effect of insulin on the parallel p38 pathway is less well understood. The present work examines the effect of inhibiting the p38 signaling pathway by use of specific inhibitors, either alone or in combination with insulin… CONTINUE READING

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