Insulin sensitization via partial agonism of PPARγ and glucose uptake through translocation and activation of GLUT4 in PI3K/p-Akt signaling pathway by embelin in type 2 diabetic rats.

@article{Gandhi2013InsulinSV,
  title={Insulin sensitization via partial agonism of PPARγ and glucose uptake through translocation and activation of GLUT4 in PI3K/p-Akt signaling pathway by embelin in type 2 diabetic rats.},
  author={Gopalsamy Rajiv Gandhi and Antony Stalin and Kedike Balakrishna and S Ignacimuthu and Michael Gabriel Paulraj and Rajagopal Vishal},
  journal={Biochimica et biophysica acta},
  year={2013},
  volume={1830 1},
  pages={2243-55}
}
BACKGROUND The present study was aimed at isolating an antidiabetic molecule from a herbal source and assessing its mechanism of action. METHODS Embelin, isolated from Embelia ribes Burm. (Myrsinaceae) fruit, was evaluated for its potential to regulate insulin resistance, alter β-cell dysfunction and modulate key markers involved in insulin sensitivity and glucose transport using high-fat diet (HFD) fed-streptozotocin (STZ) (40mg/kg)-induced type 2 diabetic rats. Molecular-dockings were… CONTINUE READING