Insulin sensitivity in cystic fibrosis.

  title={Insulin sensitivity in cystic fibrosis.},
  author={Antoinette Moran and K L Pyzdrowski and Jeffrey Weinreb and Barbara B. Kahn and Stephen J. Smith and Kevin S Adams and Elizabeth R. Seaquist},
  volume={43 8},
Cystic fibrosis (CF) patients demonstrate a spectrum of pancreatic beta-cell abnormalities. Those with no exocrine insufficiency (NEXO) have normal insulin secretion. Exocrine-insufficient CF patients with overt diabetes (EXO-IT) have impaired insulin secretion and fasting hyperglycemia. Exocrine-insufficient patients without diabetes (EXO) have impaired insulin secretion but maintain normoglycemia. We postulated that EXO individuals compensate for insulin deficiency by increasing insulin… CONTINUE READING
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