Insulin sensitivity as a key mediator of growth hormone actions on longevity.


Reduced insulin sensitivity and glucose intolerance have been long suspected of having important involvement in aging. Here we report that in studies of calorie restriction (CR) effects in mutant (Prop1(df) and growth hormone receptor knockout [GHRKO]) and normal mice, insulin sensitivity was strongly associated with longevity. Of particular interest was… (More)
DOI: 10.1093/gerona/glp024