Insulin sensitivity and insulin secretion in monozygotic and dizygotic twins

  title={Insulin sensitivity and insulin secretion in monozygotic and dizygotic twins},
  author={Maarit Lehtovirta and Jaakko M Kaprio and Carol Forsblom and J Eriksson and Jaakko Tuomilehto and Leif Groop},
Aims/hypothesis. To estimate the heritability of insulin sensitivity and insulin secretion, both of which are considered to contribute to the development of Type II (non-insulin-dependent) diabetes mellitus.¶Methods. Intraclass correlation coefficients and heritability estimates for insulin sensitivity (euglycaemic clamp) as well as first-phase and late-phase insulin secretion (intravenous glucose tolerance test) were calculated in 21 monozygotic and 20 dizygotic twin pairs of the same sex… CONTINUE READING
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