Insulin sensitivity, insulin secretion, and abdominal fat: the Insulin Resistance Atherosclerosis Study (IRAS) Family Study.

@article{Wagenknecht2003InsulinSI,
  title={Insulin sensitivity, insulin secretion, and abdominal fat: the Insulin Resistance Atherosclerosis Study (IRAS) Family Study.},
  author={Lynne E. Wagenknecht and Carl D. Langefeld and Ann L. Scherzinger and Jill M Norris and Steven M. Haffner and Mohammed F. Saad and Richard N Bergman},
  journal={Diabetes},
  year={2003},
  volume={52 10},
  pages={2490-6}
}
The relationship between insulin sensitivity and overall obesity is well established. However, there remains debate as to which of the fat depots, visceral abdominal tissue (VAT) or subcutaneous abdominal tissue (SAT), is of greater importance. Also, the relationship between fat distribution and insulin secretion is largely unknown. We studied SI, acute insulin response (AIR), and disposition index (DI), as obtained by minimal model analysis, in 999 Hispanic and 458 African-American men and… CONTINUE READING
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