Insulin secretory defects and impaired islet architecture in pancreatic beta-cell-specific STAT3 knockout mice.

@article{Gorogawa2004InsulinSD,
  title={Insulin secretory defects and impaired islet architecture in pancreatic beta-cell-specific STAT3 knockout mice.},
  author={Shin-ichi Gorogawa and Yoshio Fujitani and Hideaki Kaneto and Yoji Hazama and Hirotaka Watada and Yasuhide Miyamoto and Kiyoshi Takeda and Shizuo Akira and Mark A Magnuson and Yoshimitsu Yamasaki and Yoshitaka Kajimoto and Masatsugu Hori},
  journal={Biochemical and biophysical research communications},
  year={2004},
  volume={319 4},
  pages={1159-70}
}
Normal islet formation and function depends on the action of various growth factors operating in pre- and postnatal development; however, the specific physiological function of each factor is largely unknown. Loss-of-function analyses in mice have provided little information so far, perhaps due to functional redundancies of the growth factors acting on the… CONTINUE READING