Insulin secretion from beta-cells is affected by deletion of nicotinamide nucleotide transhydrogenase.

Abstract

Nicotinamide nucleotide transhydrogenase (NNT) is an inner mitochondrial membrane transmembrane protein involved in regenerating NADPH, coupled with proton translocation across the inner membrane. We have shown that a defect in Nnt function in the mouse, and specifically within the beta-cell, leads to a reduction in insulin secretion. This chapter describes… (More)
DOI: 10.1016/S0076-6879(09)05025-3

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Cite this paper

@article{Shimomura2009InsulinSF, title={Insulin secretion from beta-cells is affected by deletion of nicotinamide nucleotide transhydrogenase.}, author={Kenju Shimomura and Juris Galvanovskis and Michelle E. Goldsworthy and Alison J. Hugill and Stephan Kaizak and Angela Lee and Nicholas A Meadows and Mohamed Mohideen Quwailid and Jan Rydstr{\"o}m and Lydia Teboul and F. M. Ashcroft and Roger D. Cox}, journal={Methods in enzymology}, year={2009}, volume={457}, pages={451-80} }