Insulin secretion and sensitivity after partial hepatectomy in the rat.

@article{Foss1991InsulinSA,
  title={Insulin secretion and sensitivity after partial hepatectomy in the rat.},
  author={Alexander Foss and Bo Ahr{\'e}n},
  journal={Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie},
  year={1991},
  volume={191 4},
  pages={243-50}
}
It is known that following partial hepatectomy in the rat hyperinsulinemia evolves, yet glucose intolerance exists. This pattern could be explained by peripheral insulin insensitivity and a compensatory insulin hypersecretion. In the present study, we examined in vivo insulin secretion and sensitivity in partially hepatectomized rats. We found that the increase in plasma insulin levels during i.v. infusion of glucose (10 mg/min) was exaggerated at 1 and 3 days after partial (68%) hepatectomy (P… CONTINUE READING