Insulin secretion, insulin sensitivity, and hepatic insulin extraction in first-degree relatives of type 2 diabetic patients.

@article{Pimenta2003InsulinSI,
  title={Insulin secretion, insulin sensitivity, and hepatic insulin extraction in first-degree relatives of type 2 diabetic patients.},
  author={Walkyria de Paula Pimenta and Maria Luiza Carvalho Santos and N Cumpa Santa Cruz and Fl{\'a}vio Ferrari Aragon and Carlos Roberto Padovani and John E. Gerich},
  journal={Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas},
  year={2003},
  volume={36 3},
  pages={
          301-8
        }
}
To identify early metabolic abnormalities in type 2 diabetes mellitus, we measured insulin secretion, sensitivity to insulin, and hepatic insulin extraction in 48 healthy normal glucose-tolerant Brazilians, first-degree relatives of type 2 diabetic patients (FH+). Each individual was matched for sex, age, weight, and body fat distribution with a person without history of type 2 diabetes (FH-). Both groups were submitted to a hyperglycemic clamp procedure (180 mg/dl). Insulin release was… CONTINUE READING

References

Publications referenced by this paper.
SHOWING 1-10 OF 40 REFERENCES

Similar Papers

Loading similar papers…