Insulin-secreting beta-cell dysfunction induced by human lipoproteins.

  title={Insulin-secreting beta-cell dysfunction induced by human lipoproteins.},
  author={Marc-Estienne Roehrich and Vincent Mooser and Vincent Lenain and Joachim Herz and Johannes Nimpf and Salman Azhar and Martine Bideau and Alessandro M Capponi and Pascal Nicod and J. A. Haefliger and G{\'e}rard Waeber},
  journal={The Journal of biological chemistry},
  volume={278 20},
Diabetes is associated with significant changes in plasma concentrations of lipoproteins. We tested the hypothesis that lipoproteins modulate the function and survival of insulin-secreting cells. We first detected the presence of several receptors that participate in the binding and processing of plasma lipoproteins and confirmed the internalization of fluorescent low density lipoprotein (LDL) and high density lipoprotein (HDL) particles in insulin-secreting beta-cells. Purified human very low… CONTINUE READING
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