Insulin reverses the protection given by diabetes against gentamicin nephrotoxicity in the rat.

@article{Gouvea1994InsulinRT,
  title={Insulin reverses the protection given by diabetes against gentamicin nephrotoxicity in the rat.},
  author={W L Gouvea and Dan Roth and H C Alpert and Jim Kelley and Victoriano Pardo and Carlos A. Vaamonde},
  journal={Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine},
  year={1994},
  volume={206 4},
  pages={445-53}
}
Rats with untreated diabetes mellitus are protected from gentamicin-induced nephrotoxicity. In order to evaluate the role of hyperglycemia, glycosuria, and polyuria in this phenomenon, miniosmotic pumps filled with insulin were implanted for 15 days in seven female Sprague-Dawley rats with streptozotocin-induced diabetes mellitus. Plasma glucose levels were successfully maintained under 126 mg/dl. To serve as the control group, eight age-matched diabetic (plasma glucose > 400 mg/dl) rats had… CONTINUE READING