Insulin restores myocardial presynaptic sympathetic neuronal integrity in insulin-resistant diabetic rats.

@article{Thackeray2013InsulinRM,
  title={Insulin restores myocardial presynaptic sympathetic neuronal integrity in insulin-resistant diabetic rats.},
  author={James Thomas Thackeray and Robert A. deKemp and Rob S. B. Beanlands and Jean N DaSilva},
  journal={Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology},
  year={2013},
  volume={20 5},
  pages={845-56}
}
BACKGROUND Diabetes is associated with increased sympathetic activity, elevated norepinephrine, impaired heart rate variability, and the added risk of cardiovascular mortality. The temporal development of sympathetic neuronal dysfunction, response to therapy, and relation to ventricular function is not well characterized. METHODS AND RESULTS Sympathetic neuronal integrity was serially investigated in high fat diet-fed streptozotocin diabetic rats using [(11)C]meta-hydroxyephedrine (HED… CONTINUE READING
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