Insulin responsiveness of CK-M and CK-B mRNA in the diabetic rat heart.

@article{Popovich1991InsulinRO,
  title={Insulin responsiveness of CK-M and CK-B mRNA in the diabetic rat heart.},
  author={B K Popovich and M. Richard Sayen and Wolfgang H. Dillmann},
  journal={The American journal of physiology},
  year={1991},
  volume={261 3 Pt 1},
  pages={E377-81}
}
Decreased cardiac performance is a known complication of diabetes mellitus, but the detailed molecular mechanisms that are responsible for this contractile abnormality are only incompletely explored, and cardiac gene products of known function, which are markedly and actively insulin responsive, have not been described. Recently, we found that creatine kinase (CK) enzyme activity and CK-M subunit mRNA levels are decreased in the heart of rats with experimental diabetes mellitus. These… CONTINUE READING