Insulin-responsive aminopeptidase trafficking in 3T3-L1 adipocytes.

  title={Insulin-responsive aminopeptidase trafficking in 3T3-L1 adipocytes.},
  author={Luis A. Garza and Morris J Birnbaum},
  journal={The Journal of biological chemistry},
  volume={275 4},
The insulin-responsive aminopeptidase (IRAP/VP165/gp160) was identified originally in GLUT4-containing vesicles and shown to translocate in response to insulin, much like the glucose transporter 4 (GLUT4). This study characterizes the trafficking and kinetics of IRAP in exocytosis, endocytosis, and recycling to the membrane in 3T3-L1 adipocytes. After exposure of 3T3-L1 adipocytes to insulin, IRAP translocated to the plasma membrane as assessed by either cell fractionation, surface… CONTINUE READING


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23323–23327 IRAP Trafficking in 3T3-L1 Adipocytes

  • S. B. Waters, M. D’Auria, S. S. Martin, C. Nguyen, L. M. Kozma, K. L. Luskey
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