Insulin resistant young subjects at risk of accelerated atherosclerosis exhibit a marked reduction in peripheral endothelial function early in life but not differences in intima-media thickness.

@article{Balletshofer2003InsulinRY,
  title={Insulin resistant young subjects at risk of accelerated atherosclerosis exhibit a marked reduction in peripheral endothelial function early in life but not differences in intima-media thickness.},
  author={Bernd M. Balletshofer and Kilian Rittig and J. Van Der Stock and Angela Lehn-Stefan and D. Overkamp and Klaus Dietz and H. U. H{\"a}ring},
  journal={Atherosclerosis},
  year={2003},
  volume={171 2},
  pages={303-9}
}
Reduced bio-availability of nitric oxide leading to disturbed flow mediated (endothelial dependent) vasodilation (FMD) has been shown to be an early functional abnormality of the vascular system in insulin resistant individuals and other subjects at high risk for accelerated atherosclerosis. In addition, an increase of the intima-media thickness (IMT) is regarded as an early marker of morphological alterations of the vessel wall. Whether endothelial dysfunction (ED) is evident already at an… CONTINUE READING

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