Insulin-resistant brain state: the culprit in sporadic Alzheimer's disease?

  title={Insulin-resistant brain state: the culprit in sporadic Alzheimer's disease?},
  author={S{\'o}nia Catarina Correia and Renato X. Santos and George Perry and Xiongwei Zhu and Paula I Moreira and Mark A. Smith},
  journal={Ageing research reviews},
  volume={10 2},
Severe abnormalities in brain glucose/energy metabolism and insulin signaling have been documented to take a pivotal role in early sporadic Alzheimer's disease (sAD) pathology. Indeed, the "insulin-resistant brain state" has been hypothesized to form the core of the neurodegenerative events that occur in sAD. In this vein, intracerebroventricular administration of subdiabetogenic doses of streptozotocin (STZ) in rats can induce an insulin-resistant brain state, which is proposed as a suitable… CONTINUE READING