Insulin resistance syndrome predicts the risk of coronary heart disease and stroke in healthy middle-aged men: the 22-year follow-up results of the Helsinki Policemen Study.

@article{Pyrl2000InsulinRS,
  title={Insulin resistance syndrome predicts the risk of coronary heart disease and stroke in healthy middle-aged men: the 22-year follow-up results of the Helsinki Policemen Study.},
  author={M. Py{\"o}r{\"a}l{\"a} and H. Miettinen and P. Halonen and M. Laakso and K. Py{\"o}r{\"a}l{\"a}},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2000},
  volume={20 2},
  pages={
          538-44
        }
}
The interpretation of conventional multivariate analyses concerning the relation of insulin to the risk of atherosclerotic disease is complex because of correlations of insulin with other risk factors. Therefore, we applied factor analysis to study the clustering of risk factors in the baseline data of the Helsinki Policemen Study (970 healthy men aged 34 to 64 years) and investigated whether these clusterings predict coronary heart disease (CHD) and stroke risk. Areas under the glucose and… Expand
Homeostasis model assessment of insulin resistance in relation to the incidence of cardiovascular disease: the San Antonio Heart Study.
TLDR
A significant association between HOMA-IR and risk of CVD after adjustment for multiple covariates is found, however, additional studies are required, particularly among women and minority populations. Expand
Fasting hyperinsulinaemia and 2-h glycaemia predict coronary heart disease in patients with type 2 diabetes.
TLDR
Fasting insulin levels are positively associated with incidence of CHD in T2D and 2hPG appears to be a significant predictor of incident CHD independently of other risk factors, including HbA1c. Expand
Association of coronary heart disease mortality with risk factors according to length of follow-up and serum cholesterol level in men: the Oslo Study cohort
TLDR
Conventional risk factors and nonfasting triglycerides increased CHD mortality across all periods of follow-up supporting the idea that lowering cholesterol should be the primary target of primary prevention. Expand
Plasma insulin and all-cause, cardiovascular, and noncardiovascular mortality: the 22-year follow-up results of the Helsinki Policemen Study.
TLDR
Hyperinsulinemia was associated with increased all-cause and cardiovascular mortality in Helsinki policemen independent of other risk factors, although these associations weakened with the lengthening of the follow-up period. Expand
Plasma adiponectin levels are associated with insulin resistance, but do not predict future risk of coronary heart disease in women.
TLDR
It is premature to consider adiponectin as a root for vascular disease in women despite its association with insulin resistance and diabetes, and additional prospective studies are required to determine whether there is a true sex difference in the effect of adip on CHD. Expand
The Role of Age in Cardiovascular Risk Factor Clustering in Non-Diabetic Population Free of Coronary Heart Disease
TLDR
In younger subjects blood pressure was related to lipids, obesity, and glycaemia, suggesting the existence of a Metabolic Hypertension factor, while systolic and diastolic blood pressures were found to be the only significant variables in the hypertension factor after 54 years. Expand
Risk factor groupings related to insulin resistance and their synergistic effects on subclinical atherosclerosis: the atherosclerosis risk in communities study.
TLDR
Interventions aimed at ameliorating the IRS may produce reductions in atherosclerotic risk beyond that predicted by treatment of individual IRS-related risk factors. Expand
Fasting insulin concentrations and incidence of hypertension, stroke, and coronary heart disease: a meta-analysis of prospective cohort studies.
TLDR
It is suggested that early fasting insulin ascertainment in the general population may help clinicians identify those who are potentially at high risk of CVD. Expand
Inflammation markers and erythrocyte sedimentation rate but not metabolic syndrome factor score predict coronary heart disease in high socioeconomic class males: the HDDRISC study.
TLDR
Erythrocyte sedimentation rate and a factor analysis-derived measure of sub-clinical inflammation were important in the development of CHD in this relatively low-risk group, but neither metabolic syndrome factor score nor its individual components predicted CHD. Expand
Metabolic syndrome vs Framingham Risk Score for prediction of coronary heart disease, stroke, and type 2 diabetes mellitus.
TLDR
Although MetS does not predict CHD as well as the FRS, it serves well as a simple clinical tool for identifying high-risk subjects predisposed to CVD or DM2. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 53 REFERENCES
Hyperinsulinemia predicts coronary heart disease risk in healthy middle-aged men: the 22-year follow-up results of the Helsinki Policemen Study.
TLDR
Hyperinsulinemia predicted CHD risk in Helsinki policemen over the 22-year follow-up, and to a large extent independently of otherCHD risk factors, but its predictive value diminished with lengthening follow- up time. Expand
Insulin Resistance Syndrome Predicts Coronary Heart Disease Events in Elderly Nondiabetic Men
TLDR
Clustering of cardiovascular risk factors was analyzed by factor analysis to investigate whether these clusters (factors) predict CHD events in a nondiabetic population of 1069 subjects 65 to 74 years old from eastern Finland followed up for 7 years. Expand
Hyperinsulinemia and the risk of stroke in healthy middle-aged men: the 22-year follow-up results of the Helsinki Policemen Study.
TLDR
Hyperinsulinemia was associated with the risk of stroke in Helsinki policemen during the 22-year follow-up, but not independently of other risk factors, particularly upper body obesity. Expand
Prospective associations of fasting insulin, body fat distribution, and diabetes with risk of ischemic stroke. The Atherosclerosis Risk in Communities (ARIC) Study Investigators.
TLDR
Diabetes is a strong risk factor for ischemic stroke and aspects of insulin resistance, as reflected by elevated waist-to-hip ratios and elevated fasting insulin levels, may also contribute to a greater risk of isChemic stroke. Expand
Multivariate analysis of the insulin resistance syndrome in women.
TLDR
Factor analysis defined three distinct aspects of the IRS in this sample of nondiabetic women, which may reflect separate underlying mechanisms of the syndrome, each of which may also be involved in CHD risk. Expand
Risk Variable Clustering in the Insulin Resistance Syndrome: The Framingham Offspring Study
TLDR
These results were consistent with more than one independent physiological process underlying risk variable clustering: a central metabolic syndrome (characterized by hyperinsulinemia, dyslipidemia, and obesity), glucose intolerance, and hypertension. Expand
Non‐Insulin‐Dependent Diabetes and Its Metabolic Control Are Important Predictors of Stroke in Elderly Subjects
TLDR
Evidence is provided that NIDDM, its metabolic control, and the duration of diabetes are important predictors of stroke in elderly subjects, particularly in women, and fasting insulin level appears to be a risk factor for stroke in Elderly nondiabetic subjects. Expand
Insulin resistance as an independent risk factor for carotid wall thickening.
TLDR
In conclusion, insulin resistance was the strongest risk factor for carotid intima-media thickness, followed by lower high-density lipoprotein cholesterol and hypertension, and an effort to maintain normal insulin sensitivity is essential for the prevention of early atheromatous lesions in essential hypertension. Expand
Risk factor clustering in the insulin resistance syndrome. The Strong Heart Study.
TLDR
The association of clusters of risk factors and their relations with coronary heart disease provide important clues that may be used in understanding the metabolic disorders associated with insulin resistance and diabetes. Expand
Carotid Artery Wall Intima-Media Thickness Is Associated With Insulin-Mediated Glucose Disposal in Men at High and Low Coronary Risk
TLDR
The results suggest that an increase in intima-media thickness, as a possible expression of early atherosclerosis, is negatively related to insulin sensitivity index. Expand
...
1
2
3
4
5
...