Insulin resistance is a poor predictor of type 2 diabetes in individuals with no family history of disease.

@article{Goldfine2003InsulinRI,
  title={Insulin resistance is a poor predictor of type 2 diabetes in individuals with no family history of disease.},
  author={Allison B. Goldfine and Clara Bouche and Robert A. Parker and Caroline Kim and Amy S. Kerivan and Jens-Hendrik Soeldner and Blaise C Martin and James H. Warram and C Ronald Kahn},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 5},
  pages={2724-9}
}
In normoglycemic offspring of two type 2 diabetic parents, low insulin sensitivity (S(I)) and low insulin-independent glucose effectiveness (S(G)) predict the development of diabetes one to two decades later. To determine whether low S(I), low S(G,) or low acute insulin response to glucose are predictive of diabetes in a population at low genetic risk for disease, 181 normoglycemic individuals with no family history of diabetes (FH-) and 150 normoglycemic offspring of two type 2 diabetic… CONTINUE READING