Insulin resistance induced by sucrose feeding in rats is due to an impairment of the hepatic parasympathetic nerves

@article{Ribeiro2005InsulinRI,
  title={Insulin resistance induced by sucrose feeding in rats is due to an impairment of the hepatic parasympathetic nerves},
  author={Rog{\'e}rio T. Ribeiro and Wilford Wayne Lautt and Dallas J. Legare and M Paula Macedo},
  journal={Diabetologia},
  year={2005},
  volume={48},
  pages={976-983}
}
Aims/hypothesisA considerable proportion of whole-body insulin-stimulated glucose uptake is dependent upon the hepatic insulin-sensitising substance (HISS) in a pathway mediated by the hepatic parasympathetic nerves (HPNs). We tested the hypothesis that a high-sucrose diet leads to the impairment of the HPN-dependent component of insulin action.MethodsWe quantified insulin sensitivity using the rapid insulin sensitivity test, a modified euglycaemic clamp. Quantification of the HPN-dependent… CONTINUE READING
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