Insulin resistance in the skeletal muscle of women with PCOS involves intrinsic and acquired defects in insulin signaling.

@article{Corbould2005InsulinRI,
  title={Insulin resistance in the skeletal muscle of women with PCOS involves intrinsic and acquired defects in insulin signaling.},
  author={Anne Corbould and Young-Bum Kim and Jack F. Youngren and Celia Pender and Barbara B. Kahn and Anna E Lee and Andrea Dunaif},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2005},
  volume={288 5},
  pages={E1047-54}
}
Insulin resistance in polycystic ovary syndrome (PCOS) is due to a postbinding defect in signaling that persists in cultured skin fibroblasts and is associated with constitutive serine phosphorylation of the insulin receptor (IR). Cultured skeletal muscle from obese women with PCOS and age- and body mass index-matched control women (n = 10/group) was… CONTINUE READING