Insulin resistance in equine digital vessel rings: an in vitro model to study vascular dysfunction in equine laminitis.

@article{Venugopal2011InsulinRI,
  title={Insulin resistance in equine digital vessel rings: an in vitro model to study vascular dysfunction in equine laminitis.},
  author={Changaram S. Venugopal and S Eades and Earnestine P Holmes and Ralph E. Beadle},
  journal={Equine veterinary journal},
  year={2011},
  volume={43 6},
  pages={744-9}
}
REASONS FOR PERFORMING STUDY One of the causes of equine laminitis is hyperinsulinaemia, which may be associated with endothelial dysfunction and insulin resistance of vessels. HYPOTHESIS AND OBJECTIVES Insulin resistance can be induced in palmar digital vessels by continued exposure to insulin in vitro. The objective was to evaluate this in vitro model for future studies. METHODS Palmar digital vessel segments were collected immediately after euthanasia from horses with normal insulin… CONTINUE READING