Insulin resistance in depressive disorders and Alzheimer's disease: revisiting the missing link hypothesis.

@article{Rasgon2005InsulinRI,
  title={Insulin resistance in depressive disorders and Alzheimer's disease: revisiting the missing link hypothesis.},
  author={Natalie L. Rasgon and Heather A. Kenna},
  journal={Neurobiology of aging},
  year={2005},
  volume={26 Suppl 1},
  pages={103-7}
}
Several lines of evidence suggest an association between depressive disorders and Alzheimer's disease (AD). We previously suggested central nervous system (CNS) effects of insulin resistance (IR) to be an important link between depressive disorders and AD. Although the exact mechanism of central IR is not known, it is thought that central IR results in inadequate glucose metabolism in the brain. According to our hypothesis, inadequate glucose utilization resulting from IR underlies neuronal… CONTINUE READING

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