Insulin resistance impairs sustained virological response rate to pegylated interferon plus ribavirin in HIV-hepatitis C virus-coinfected patients: HOMAVIC-ANRS HC02 Study.

@article{Cacoub2009InsulinRI,
  title={Insulin resistance impairs sustained virological response rate to pegylated interferon plus ribavirin in HIV-hepatitis C virus-coinfected patients: HOMAVIC-ANRS HC02 Study.},
  author={Patrice Cacoub and Fabrice Carrat and Pierre Bedossa and J{\^e}rome Lambert and Guillaume Penaranda and Stanislas Pol and Philippe Halfon},
  journal={Antiviral therapy},
  year={2009},
  volume={14 6},
  pages={839-45}
}
BACKGROUND The aim of this study was to assess the effect of insulin resistance (IR) on the response to hepatitis C virus (HCV) therapy in HIV-HCV-coinfected patients. METHODS A total of 238 HIV-HCV-coinfected patients (74% male, mean +/-sd age 40 +/-5 years, mean alcohol intake <50 g/day and 38% HCV genotype 2 or 3), treated by standard or pegylated interferon-alpha2b plus ribavirin during 48 weeks were studied. Liver biopsies were assessed before treatment. Patients were considered to have… CONTINUE READING
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