Insulin resistance impairs cutaneous wound healing in mice.

  title={Insulin resistance impairs cutaneous wound healing in mice.},
  author={Marcela Otranto and Adriana Paulino do Nascimento and Andr{\'e}a Monte-Alto-Costa},
  journal={Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society},
  volume={21 3},
Obesity is associated with significant changes in skin combined with metabolic alterations such as insulin resistance. Our aim was to investigate the effects of insulin resistance induced by a high-fat diet on cutaneous wound healing. Male C57BL/6 mice were fed standard chow (SC group) or high-fat chow (HFC group) for 30 weeks. On day 0 (28th week), an excisional wound was performed. After 14 days (30th week), the mice were euthanized. Starting from the 8th week, the HFC group had a higher body… CONTINUE READING