Insulin resistance due to phosphorylation of insulin receptor substrate-1 at serine 302.

@article{Werner2004InsulinRD,
  title={Insulin resistance due to phosphorylation of insulin receptor substrate-1 at serine 302.},
  author={Eric D Werner and Jongsoon Lee and Lone Holm Hansen and Minsheng Yuan and Steven E. Shoelson},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 34},
  pages={35298-305}
}
Inhibitory serine phosphorylation is a potential molecular mechanism for insulin resistance. We have developed a new variant of the yeast two-hybrid method, referred to as disruptive yeast tri-hybrid (Y3H), to identify inhibitory kinases and sites of phosphorylation in insulin receptors (IR) and IR substrates, IRS-1. Using IR and IRS-1 as bait and prey, respectively, and c-Jun NH(2)-terminal kinase (JNK1) as the disruptor, we now show that phosphorylation of IRS-1 Ser-307, a previously… CONTINUE READING

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