Insulin resistance as the major cause of impaired glucose tolerance: a self-fulfilling prophesy?

@article{ORahilly1994InsulinRA,
  title={Insulin resistance as the major cause of impaired glucose tolerance: a self-fulfilling prophesy?},
  author={Stephen O'Rahilly and Hooshang Gray and Andrew T Hattersley and Allan Vaag},
  journal={The Lancet},
  year={1994},
  volume={344},
  pages={585-589}
}
Non-insulin-dependent diabetes (NIDDM) is a heterogeneous state involving various degrees of beta-cell dysfunction and insulin resistance, although the relative importance of these two factors is controversial. Several single gene disorders of carbohydrate metabolism have their main pathophysiological defect largely restricted to the beta-cell or to insulin-sensitive tissues. We have noted that with insulin resistance the fasting plasma glucose is often normal and severe hyperglycaemia occurs… CONTINUE READING
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