Insulin resistance and the metabolism of branched-chain amino acids in humans

@article{Adeva2011InsulinRA,
  title={Insulin resistance and the metabolism of branched-chain amino acids in humans},
  author={Mar{\'i}a M. Adeva and Jes{\'u}s Calvi{\~n}o and G. F. Souto and Crist{\'o}bal Donapetry},
  journal={Amino Acids},
  year={2011},
  volume={43},
  pages={171-181}
}
Peripheral resistance to insulin action is the major mechanism causing the metabolic syndrome and eventually type 2 diabetes mellitus. The metabolic derangement associated with insulin resistance is extensive and not restricted to carbohydrates. The branched-chain amino acids (BCAAs) are particularly responsive to the inhibitory insulin action on amino acid release by skeletal muscle and their metabolism is profoundly altered in conditions featuring insulin resistance, insulin deficiency, or… CONTINUE READING
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