Insulin resistance and insulin deficiency in the pathogenesis of posttransplantation diabetes in man.

@article{Ekstrand1992InsulinRA,
  title={Insulin resistance and insulin deficiency in the pathogenesis of posttransplantation diabetes in man.},
  author={Agneta Vivianne Ekstrand and Johan G Eriksson and Carola Gr{\"o}nhagen-Riska and Pekka Ahonen and Leif Groop},
  journal={Transplantation},
  year={1992},
  volume={53 3},
  pages={563-9}
}
Although steroids can induce insulin resistance, it is not known whether additional defects in insulin secretion are necessary for the development of diabetes. To address this question, we measured insulin sensitivity (euglycemic insulin clamp in combination with indirect calorimetry and infusion of tritiated glucose) and insulin secretion (hyperglycemic clamp) in three groups of subjects: (1) 10 kidney transplant patients with normal oral glucose tolerance, (2) 14 patients who developed… CONTINUE READING
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