Insulin resistance and hyperinsulinemia in homozygous beta-thalassemia.

  title={Insulin resistance and hyperinsulinemia in homozygous beta-thalassemia.},
  author={Paolo Cavallo-Perin and Giovanni Pacini and Franco Cerutti and A Bessone and C Cond{\`o} and Lucia Sacchetti and Antonio Morales Piga and Gianfranco Pagano},
  journal={Metabolism: clinical and experimental},
  volume={44 3},
Insulin resistance and hyperinsulinemia have been reported in homozygous beta-thalassemia before the development of diabetes. However, insulin sensitivity (SI) has never been studied in normoinsulinemic patients. Furthermore, whether hyperinsulinemia is due to increased beta-cell secretion or to decreased hepatic insulin extraction is poorly understood. We estimated SI, beta-cell secretion, and hepatic insulin extraction using the minimal model analysis of a frequently sampled intravenous… CONTINUE READING