Insulin resistance and glycine metabolism in humans

@article{AdevaAndany2017InsulinRA,
  title={Insulin resistance and glycine metabolism in humans},
  author={Mar{\'i}a M. Adeva-Andany and G. Souto-Adeva and Eva Ameneiros-Rodr{\'i}guez and Carlos Fern{\'a}ndez-Fern{\'a}ndez and Crist{\'o}bal Donapetry-Garc{\'i}a and Alberto Dom{\'i}nguez-Montero},
  journal={Amino Acids},
  year={2017},
  volume={50},
  pages={11-27}
}
Plasma glycine level is low in patients with obesity or diabetes and the improvement of insulin resistance increases plasma glycine concentration. In prospective studies, hypoglycinemia at baseline predicts the risk of developing type 2 diabetes and higher serum glycine level is associated with decreased risk of incident type 2 diabetes. Consistently, plasma glycine concentration is lower in the lean offspring of parents with type 2 diabetes compared to healthy subjects. Among patients with… 
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