Insulin resistance and amyloidogenesis as common molecular foundation for type 2 diabetes and Alzheimer's disease.

@article{Zhao2009InsulinRA,
  title={Insulin resistance and amyloidogenesis as common molecular foundation for type 2 diabetes and Alzheimer's disease.},
  author={Wei-qin Zhao and Matthew T Townsend},
  journal={Biochimica et biophysica acta},
  year={2009},
  volume={1792 5},
  pages={482-96}
}
Characterized as a peripheral metabolic disorder and a degenerative disease of the central nervous system respectively, it is now widely recognized that type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD) share several common abnormalities including impaired glucose metabolism, increased oxidative stress, insulin resistance and amyloidogenesis. Several recent studies suggest that this is not an epiphenomenon, but rather these two diseases disrupt common molecular pathways and each… CONTINUE READING
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