Insulin resistance affects the cytoprotective effect of insulin in cardiomyocytes through an impairment of MAPK phosphatase-1 expression.

@article{Morisco2007InsulinRA,
  title={Insulin resistance affects the cytoprotective effect of insulin in cardiomyocytes through an impairment of MAPK phosphatase-1 expression.},
  author={Carmine Morisco and C. A. Quintero Marrone and Valentina Trimarco and Salvatore Crispo and Maria Gaia Monti and Junichi Sadoshima and Bruno Trimarco},
  journal={Cardiovascular research},
  year={2007},
  volume={76 3},
  pages={453-64}
}
OBJECTIVE Insulin protects cardiomyocytes from apoptosis. Insulin resistance usually refers to a defect in the ability of insulin to stimulate glucose uptake. It is unknown, however, whether or not insulin resistance compromises the cell-protective effect of the hormone. Caspases are a family of cysteine proteases that regulate apoptosis. We explored the effects of insulin resistance on hypoxia-induced caspase-3 activation in cardiomyocytes. METHODS Experiments were performed in cultured… CONTINUE READING

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