Insulin resistance accelerates a dietary rat model of nonalcoholic steatohepatitis.

  title={Insulin resistance accelerates a dietary rat model of nonalcoholic steatohepatitis.},
  author={Tsuguhito Ota and Toshinari Takamura and Seiichiro Kurita and Naoto Matsuzawa and Yuki Kita and Masafumi Uno and Hiroshi Akahori and Hirofumi Misu and Masaru Sakurai and Yoh Zen and Yasuni Nakanuma and Shuichi Kaneko},
  volume={132 1},
BACKGROUND & AIMS The increasing prevalence of nonalcoholic steatohepatitis (NASH) is due to the epidemic of obesity and type 2 diabetes, both of which are associated with insulin resistance. METHODS To clarify the causal relationship between insulin resistance and the development of NASH, steatohepatitis was induced in obese diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) and nondiabetic control Long-Evans Tokushima Otsuka (LETO) rats by feeding them a methionine and choline-deficient… CONTINUE READING
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