Insulin resistance: a chicken that has come to roost.

@article{Reaven1999InsulinRA,
  title={Insulin resistance: a chicken that has come to roost.},
  author={Gerald Mark Reaven},
  journal={Annals of the New York Academy of Sciences},
  year={1999},
  volume={892},
  pages={45-57}
}
Insulin-mediated glucose disposal varies approximately 10-fold in apparently healthy human beings. Insulin (I)-resistant individuals can remain glucose tolerant if the pancreas compensates for this defect by secreting large amounts of I. Type 2 diabetes develops when I-resistant persons cannot sustain this state of compensatory hyperinsulinemia (increases I… CONTINUE READING