Insulin release in impaired glucose tolerance: oral minimal model predicts normal sensitivity to glucose but defective response times.

@article{Breda2002InsulinRI,
  title={Insulin release in impaired glucose tolerance: oral minimal model predicts normal sensitivity to glucose but defective response times.},
  author={Elena Breda and Gianna Toffolo and Kenneth S. Polonsky and Claudio Cobelli},
  journal={Diabetes},
  year={2002},
  volume={51 Suppl 1},
  pages={S227-33}
}
The availability of quantitative indexes describing beta-cell function in normal life conditions is important for the characterization of impaired mechanisms of insulin secretion in pathophysiological states. Recently, an oral C-peptide minimal model has been proposed and applied to subjects with normal glucose tolerance (NGT) during graded up-and-down glucose infusion protocols (40-min periods at 4, 8, 16, 8, 4, and 0 mg.kg(-1).min(-1)) and oral glucose tolerance tests. These tests are… CONTINUE READING

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