Insulin release from a cloned hamster B-cell line (HIT-T15). The effects of glucose, amino acids, sulphonylureas and colchicine.

@article{Lambert1986InsulinRF,
  title={Insulin release from a cloned hamster B-cell line (HIT-T15). The effects of glucose, amino acids, sulphonylureas and colchicine.},
  author={David George Lambert and K Hughes and Terence William Atkins},
  journal={Biochemical and biophysical research communications},
  year={1986},
  volume={140 2},
  pages={
          616-25
        }
}
  • David George Lambert, K Hughes, Terence William Atkins
  • Published 1986
  • Biology, Medicine
  • Biochemical and biophysical research communications
  • Insulin release from statically incubated HIT-T15 cells was maximally stimulated by glucose, L-arginine and L-leucine. L-arginine stimulated insulin release in the absence of glucose. Glucose induced insulin release was potentiated by the addition of L-leucine, L-arginine and the two in combination. Both glibenclamide and chlorpropamide stimulated insulin release from HIT-T15 cells. Glibenclamide was the more potent and equivalent in insulinotrophic action to 7.5 mmol/l glucose. Only… CONTINUE READING

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