Insulin release : the fuel concept.

  title={Insulin release : the fuel concept.},
  author={Willy Jean Malaisse},
  journal={Diabete & metabolisme},
  volume={9 4},
Insulin release evoked by nutrient secretagogues invariably coincides with an increase in the catabolism of exogenous and/or endogenous nutrients in pancreatic islet cells, resulting in an increased generation rate of reducing equivalents and ATP, and an increase in O2 consumption. This situation was documented in response to a number of carbohydrates, including the anomers of D-glucose and D-mannose, various 2-keto acids, including pyruvate and its poorly oxidized phenylated analog 3… CONTINUE READING


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