Insulin regulation of lipoprotein lipase activity in 3T3-L1 adipocytes is mediated at posttranscriptional and posttranslational levels.

@article{Semenkovich1989InsulinRO,
  title={Insulin regulation of lipoprotein lipase activity in 3T3-L1 adipocytes is mediated at posttranscriptional and posttranslational levels.},
  author={Clay F Semenkovich and M E Wims and Liesbet Noe and Jacqueline Etienne and Lawrence K Chan},
  journal={The Journal of biological chemistry},
  year={1989},
  volume={264 15},
  pages={
          9030-8
        }
}
Insulin is a major regulator of lipoprotein lipase (LPL) activity. The molecular events associated with LPL regulation by insulin in 3T3-L1 adipocytes were studied by determining LPL enzyme activity, mRNA levels, protein synthetic rate, and transcription run-off activity. Adipocytes treated with insulin (10(-6) M for 48 h) had substantially higher LPL activity (mean difference compared to carrier-treated cells 146%) with little difference in LPL mRNA levels (mean level 109% of control). Insulin… CONTINUE READING
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