Insulin regulation of insulin-like growth factor action in rat hepatoma cells.

@article{Heaton1984InsulinRO,
  title={Insulin regulation of insulin-like growth factor action in rat hepatoma cells.},
  author={J. Henniker Heaton and Nancy L. Krett and Jos{\'e} Maria {\'A}lvarez and Thomas D. Gelehrter and Joakim Romanus and Matthew M. Rechler},
  journal={The Journal of biological chemistry},
  year={1984},
  volume={259 4},
  pages={
          2396-402
        }
}
We have reported previously that insulin causes a complete but reversible desensitization to insulin action in rat hepatoma HTC cells in tissue culture, and that this insulin resistance is mediated by postbinding mechanisms rather than receptor down-regulation (Heaton, J. H., and Gelehrter, T. D. (1981) J. Biol. Chem. 256, 12257-12262). We report here that insulin causes a similar desensitization to the induction of tyrosine aminotransferase by the insulin-like growth factors IGF-I and IGF-II… CONTINUE READING

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