Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1

  title={Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1},
  author={Mingjian Lu and Min Wan and Karla F. Leavens and Qingwei Chu and Bobby R. Monks and Sully Fernandez and Rexford S. Ahima and Kohjiro Ueki and C Ronald Kahn and Morris J Birnbaum},
  booktitle={Nature Medicine},
Considerable data support the idea that forkhead box O1 (Foxo1) drives the liver transcriptional program during fasting and is then inhibited by thymoma viral proto-oncogene 1 (Akt) after feeding. Here we show that mice with hepatic deletion of Akt1 and Akt2 were glucose intolerant, insulin resistant and defective in their transcriptional response to feeding in the liver. These defects were normalized with concomitant liver-specific deletion of Foxo1. Notably, in the absence of both Akt and… CONTINUE READING
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