Insulin regulates alveolar epithelial function by inducing Na+/K+-ATPase translocation to the plasma membrane in a process mediated by the action of Akt.

@article{Comellas2010InsulinRA,
  title={Insulin regulates alveolar epithelial function by inducing Na+/K+-ATPase translocation to the plasma membrane in a process mediated by the action of Akt.},
  author={Alejandro P Comellas and Aileen M. Kelly and Humberto E. Trejo and Arturo Briva and Joyce Yeuk Yu Lee and Jacob I Sznajder and Laura A Dada},
  journal={Journal of cell science},
  year={2010},
  volume={123 Pt 8},
  pages={1343-51}
}
Stimulation of Na(+)/K(+)-ATPase translocation to the cell surface increases active Na(+) transport, which is the driving force of alveolar fluid reabsorption, a process necessary to keep the lungs free of edema and to allow normal gas exchange. Here, we provide evidence that insulin increases alveolar fluid reabsorption and Na(+)/K(+)-ATPase activity by increasing its translocation to the plasma membrane in alveolar epithelial cells. Insulin-induced Akt activation is necessary and sufficient… CONTINUE READING

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