Insulin regulates adipocyte lipolysis via an Akt-independent signaling pathway.

@article{Choi2010InsulinRA,
  title={Insulin regulates adipocyte lipolysis via an Akt-independent signaling pathway.},
  author={Sarah M Choi and David F. Tucker and Danielle N Gross and Rachael M. Easton and Lisa M. DiPilato and Abigail S Dean and Bob R Monks and Morris J Birnbaum},
  journal={Molecular and cellular biology},
  year={2010},
  volume={30 21},
  pages={
          5009-20
        }
}
After a meal, insulin suppresses lipolysis through the activation of its downstream kinase, Akt, resulting in the inhibition of protein kinase A (PKA), the main positive effector of lipolysis. During insulin resistance, this process is ineffective, leading to a characteristic dyslipidemia and the worsening of impaired insulin action and obesity. Here, we describe a noncanonical Akt-independent, phosphoinositide-3 kinase (PI3K)-dependent pathway that regulates adipocyte lipolysis using… CONTINUE READING
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