Insulin-regulated release from the endosomal recycling compartment is regulated by budding of specialized vesicles.

@article{Lampson2001InsulinregulatedRF,
  title={Insulin-regulated release from the endosomal recycling compartment is regulated by budding of specialized vesicles.},
  author={Michael A Lampson and Jan Schmoranzer and Anja Zeigerer and Sanford M Simon and Timothy E McGraw},
  journal={Molecular biology of the cell},
  year={2001},
  volume={12 11},
  pages={
          3489-501
        }
}
In several cell types, specific membrane proteins are retained intracellularly and rapidly redistributed to the surface in response to stimulation. In fat and muscle, the GLUT4 glucose transporter is dynamically retained because it is rapidly internalized and slowly recycled to the plasma membrane. Insulin increases the recycling of GLUT4, resulting in a net translocation to the surface. We have shown that fibroblasts also have an insulin-regulated recycling mechanism. Here we show that GLUT4… CONTINUE READING
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