Insulin-regulated increase of soluble vascular adhesion protein-1 in diabetes.

  title={Insulin-regulated increase of soluble vascular adhesion protein-1 in diabetes.},
  author={Marko Salmi and Craig M Stolen and Pekka J Jousilahti and Gennady G Yegutkin and P{\"a}ivi Tapanainen and Tuula Janatuinen and Mikael Knip and Sirpa Jalkanen and Veikko V Salomaa},
  journal={The American journal of pathology},
  volume={161 6},
Vascular adhesion protein-1 (VAP-1) is one of the molecules on the endothelial cell membrane, which may guide inflammatory cells into atherosclerotic lesions. This dual function molecule may also contribute to the pathogenesis of atherosclerosis and other vasculopathies via its enzymatic activity that oxidizes primary amines to produce their corresponding aldehydes, hydrogen peroxide, and ammonium. Because VAP-1 also exists in a soluble form, we analyzed its potential usefulness as a biomarker… CONTINUE READING