Insulin-regulated aminopeptidase in adipocyte is Cys-specific and affected by obesity.

  title={Insulin-regulated aminopeptidase in adipocyte is Cys-specific and affected by obesity.},
  author={Rafaela Fadoni Alponti and Luciana Godoy Viana and Norma Yamanouye and Paulo Fl{\'a}vio Silveira},
  journal={Journal of molecular endocrinology},
  volume={55 1},
Insulin-regulated aminopeptidase (IRAP, EC in adipocytes is well known to traffic between high (HDM) and low (LDM) density microsomal fractions toward the plasma membrane (MF) under stimulation by insulin. However, its catalytic preference for aminoacyl substrates with N-terminal Leu or Cys is controversial. Furthermore, possible changes in its traffic under metabolic challenges are unknown. The present study investigated the catalytic activity attributable to EC in HDM, LDM… 

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